Cold exposure induces transcriptomic and metabolic reprogramming in the heart: An integrated multiomics study

doi: 10.1515/fzm-2026-0010

• Jiaming Ju^{1, 2, #} , 
• Zhengchao Wen^{2, #} , 
• Jiayun Li² , 
• Dandan Zhang² , 
• Kejiao Zhang² , 
• Haozhan Wang² , 
• Roman E. Tokmachev³ , 
• Yang Li^{4, 5 ,  ,}  , 
• Yanan Jiang^{1, 2, 6 ,  ,} 

• 1.

  State Key Laboratory of Frigid Zone Cardiovascular Diseases (SKLFZCD), Department of Pharmacology (State Key Laboratory -Province Key Laboratories of Biomedicine-Pharmaceutics of China), College of Pharmacy, Harbin Medical University, Harbin 150081, China

• 2.

  Translational Medicine Research and Cooperation Center of Northern China, Heilongjiang Academy of Medical Sciences, Harbin 150086, China

• 3.

  The N.N. Burdenko VSMU Experimental Biology and Medicine Research Institute, Voronezh State Medical University named after N. N. Burdenko, Voronezh 394043, Russia

• 4.

  Center for Endemic Disease Control, Chinese Center for Disease Control and Prevention, Harbin Medical University, Harbin 150081, China

• 5.

  NHC Key Laboratory of Etiology and Epidemiology (Harbin Medical University); Heilongjiang Provincial Key Laboratory of Trace Elements and Human Health (Harbin Medical University); Key Laboratory of Etiology and Epidemiology, Education Bureau of Heilongjiang Province (Harbin Medical University), Harbin 150081, China

• 6.

  Department of Oral and Maxillofacial Surgery, The First Affiliated Hospital, Harbin Medical University, Harbin 150081, China