2022 Vol. 2, No. 2

Display Method:
Review
Dissecting pathophysiology of a human dominantly inherited disease, familial amyloidotic polyneuropathy, by using genetically engineered mice
Zhenghua Li, Kenichi Yamamura
2022, 2(2): 65-75. doi: 10.2478/fzm-2022-0009
Abstract:
Familial amyloidotic polyneuropathy (FAP) is a type of systemic amyloidosis characterized by peripheral and autonomic neuropathy. Although FAP is a typical autosomal dominant disorder caused by a point mutation in the TTR gene, the average age at onset varies significantly among different countries....
Effect of cold on knee osteoarthritis: Recent research status
Haile Pan, Zilong Shen, Qi Chen, Rui Jiang, Yongchen Wang
2022, 2(2): 76-81. doi: 10.2478/fzm-2022-0010
Abstract:
Osteoarthritis is a common chronic irreversible joint disease characterized by degenerative changes of articular cartilage and secondary hyper osteogeny. Knee osteoarthritis(KOA) affects not only the articular cartilage, but also the entire joint, including subchondral bone, joint capsule, synovial ...
Original Article
Effects of intermittent cold-exposure on culprit plaque morphology in ST-segment elevation myocardial infarction patients: a retrospective study based on optical coherence tomography
Jinxin Liu, Shaohong Fang, Shanjie Wang, Changbin Sun, Rong Sun, Hengxuan Cai, Bo Yu
2022, 2(2): 82-89. doi: 10.2478/fzm-2022-0011
Abstract:
Objective Present study aimed to explore the effects of intermittent cold-exposure (ICE) on culprit plaque morphology in patients with STsegment elevation myocardial infarction (STEMI) in frigid zone. Methods Totally 848 STEMI patients with plaque rupture (N = 637) or plaque erosion (N = 211) were e...
A randomized retrospective clinical study on the choice between endodontic surgery and immediate implantation
Garegin Movsesyan, Edita Margaryan, Marianna Arakelyan, Mikhail Stepanov
2022, 2(2): 90-93. doi: 10.2478/fzm-2022-0012
Abstract:
Background Periapical endodontic surgery (PES) for root amputation and tooth replacement by immediate implant placement are two possible treatment options for bone lesions in the root apex of a tooth that has previously undergone endodontic treatment. Treatment methods are performed when the effecti...
Challenges and improvement in management of neonates born to mothers with COVID-19 in China
Jie Yang, Zhuxiao Ren, Lingkong Zeng, Shiwen Xia, Lin Wang, Jiayu Miao, Zhe Zhao, Chuanzhong Yang, Xiuyong Cheng, Huayan Zhang, Yuanfang Zhu, Li Liu, Xirong Gao, Bin Yi, Zhenlang Lin, Wei Liu, Xiaoyu Zhou, Benqing Wu, Ling Chen, Zhankui Li, Xuefeng Zhang, Wei Lu, Lianhong Zhang, Xiao Chen, Xiaoyun Zhong, Falin Xu, Jinhui Wu, Yong Ji, Jiahua Pan, Yanxiang Chen, Carine Ronsmans, Zhichun Feng, on behalf of the Chinese Neonatologist Association
2022, 2(2): 94-102. doi: 10.2478/fzm-2022-0013
Abstract:
Objective China was the first country suffering from the SARS-CoV-2 pandemic and one of the countries with stringent mother-neonate isolation measure implemented. Now increasing evidence suggests that coronavirus disease 2019 (COVID-19) should not be taken as an indication for formula feeding or iso...
Nortriterpenoids from the fruit stalk of Schisandra chinensis (Turcz.) Baill.
Yan Liu, Xiaohui Rong, Yuanhang Chang, Juan Pan, Wei Guan, Haixue Kuang, Bingyou Yang
2022, 2(2): 103-108. doi: 10.2478/fzm-2022-0014
Abstract:
Objective The fruit stalk of Schisandra chinensis (Turcz.) Baill. (S. chinensis) has been found to contain bioactive components similar to the fruit of S. chinensis. Here, we report a recent discovery about new nortriterpenoids with a novel skeleton and anti-gastric cancer activity, which were isola...
Altered expression profile of long non-coding RNAs during heart aging in mice
Xiuxiu Wang, Bingjie Hua, Meixi Yu, Shenzhen Liu, Wenya Ma, Fengzhi Ding, Qi Huang, Lai Zhang, Chongwei Bi, Ye Yuan, Mengyu Jin, Tianyi Liu, Ying Yu, Benzhi Cai, Baofeng Yang
2022, 2(2): 109-118. doi: 10.2478/fzm-2022-0015
Abstract:
Objective Long noncoding RNAs (lncRNAs) play an important role in regulating the occurrence and development of cardiovascular diseases. However, the role of lncRNAs in heart aging remains poorly understood. The objective of this study was to identify differentially expressed lncRNAs in the heart of ...
Cryptotanshinone increases the sensitivity of liver cancer to sorafenib by inhibiting the STAT3/Snail/epithelial mesenchymal transition pathway
Zhiyu Li, Kegong Chen, Chao Cui, Yinghui Wang, Dequan Wu
2022, 2(2): 119-128. doi: 10.2478/fzm-2022-0016
Abstract:
Objective Sorafenib resistance has been a major factor limiting its clinical use as a targeted drug in liver cancer. The present study aimed to investigate whether cryptotanshinone can enhance the sensitivity of liver cancer and reduce the resistance to sorafenib. Methods Sorafenib-resistant cells w...