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The link between dietary nutrients intake and cardiovascular diseases in cold regions
Rennan Feng, Qianqi Hong, Jingjing Cao, Jian Li, Lanxin Deng, Jing Wang, Yang Zhao, Cheng Wang
2024, 4(1): 1-11. doi: 10.2478/fzm-2024-0001
Keywords: nutrients, northern, hypertension, coronary heart disease, cold
  Background  The cold winter weather in northern China influences the dietary habits of its residents, contributing to a heightened risk of cardiovascular disorders, such as hypertension and coronary heart disease. Key factors include low vegetable consumption and high salt and fat intakes. This study aims to investigate the relationships between northern dietary nutrient intake in northern China and cardiovascular disorders during the winter season.  Methods  A food frequency questionnaire tailored to the actual eating habits in northern China was designed. Retrospective data from 955 Chinese adults were collected from November to March between 2014 to 2023. Logistic regression was employed to analyze the relationship between dietary nutrients and cardiovascular diseases, with model performance assessed using receiver operating characteristic (ROC) curves.  Results  Adjusted for gender, age, and body mass index (BMI), an inverse association was observed between vitamin A (OR = 0.706, 95% CI: 0.550, 0.907), nicotinic acid (OR = 0.584, 95% CI: 0.447, 0.762), phosphorus (OR = 0.777, 95% CI: 0.608, 0.994), selenium (OR = 0.719, 95% CI: 0.560, 0.923), zinc (OR = 0.683, 95% CI: 0.531, 0.880), methionine (OR = 0.730, 95% CI: 0.569, 0.936), arginine (OR = 0.753, 95% CI: 0.588, 0.964), lysine (OR = 0.706, 95% CI: 0.550, 0.907), aspartic acid (OR = 0.730, 95% CI: 0.569, 0.936) and hypertension. Additionally, a negative association was found between niacin (OR = 0.752, 95% CI: 0.597, 0.946) and coronary heart disease. Conversely, a positive association was identified between iodine and hypertension (OR = 1.305, 95% CI: 1.020, 1.669) and coronary heart disease (OR = 1.301, 95% CI: 1.037, 1.634).  Conclusion  Our study suggests that maintaining a balanced dietary intake of vitamin A, niacin, phosphorus, selenium, zinc, methionine, arginine, lysine, and aspartic acid can be beneficial in preventing hypertension. Adequate niacin intake is associated with a lower risk of coronary heart disease. However, excessive iodine intake may contribute to hypertension and coronary heart disease.
Correlation of PM2.5 pollution and daily mortality rate of cardiovascular and cerebrovascular diseases in Northeast China through PM2.5 sources analysis
Qianqi Hong, Yang Zhao, Jing Wang, Hongyan Sun, Lanxin Deng, Jingjing Cao, Cheng Wang
2024, 4(4): 193-201. doi: 10.1515/fzm-2024-0019
Keywords: PM2.5, cardio-cerebrovascular diseases, daily mortality, time series, PMF
  Objective   This study aims to evaluate the relationship between PM2.5 concentration and daily mortality rate from cardiovascular and cerebrovascular diseases (CCVD) in cold regions of northern China, as well as to identify the primary sources of PM2.5.   Methods   A time series analysis model was used to calculate the exposure-response relationship between PM2.5 and CCVD mortality in Harbin. Positive matrix factorization (PMF) was employed to analyze the sources of PM2.5.   Results   After adjusting for multiple pollutant combinations, the maximum excess risk of cardio-cerebrovascular death on the day of PM2.5 exposure was 0.42% (95% CI: 0.15%-0.70%). Stratification by gender and age revealed that the elderly individuals and men were particularly susceptible to PM2.5 exposure. The source analysis identified seven major pollution sources contributing to PM2.5 in Harbin.   Conclusion   Our findings strengthen the evidence that PM2.5 is an independent risk factor for daily CCVD mortality, identify vulnerable populations that require special attention, and pinpoint the primary sources of PM2.5 in Harbin. These findings provide reference points for effectively reducing the health risks associated with PM2.5 exposure.
Metabolomics study on dibenz[a, h]anthracene exposure-induced pulmonary injury in rats after intratracheal instillation
Zhen Kang, Qianqi Hong, Fei Yan, Tianyi Yu, Yuna Bai, Xiaobo Liu, Xiaolin Na, Cheng Wang
2025, 5(1): 42-49. doi: 10.1515/fzm-2025-0004
Keywords: DahA, metabolomics, pulmonary injury, heating season
  Background  Northern residents predominantly rely on coal-fired heating during winter, leading to severe air pollution. Polycyclic aromatic hydrocarbons (PAHs) adsorbed on atmospheric particulate matter pose significant health risks. Among PAHs, dibenz[a, h]anthracene (DahA), though present at lower environmental concentrations compared to other PAHs, exhibits a carcinogenic potency that is 10 or more times greater than benzo[a]pyrene (BaP), underscoring its potential harm. Despite reports on DahA's multiple toxic effects, its impact on metabolic networks remains poorly understood.  Methods  Based on the respiratory volume of adult rats and the concentration of PM2.5-bound DahA in heavily polluted cities of northern China, adult Sprague-Dawley rats were treated with DahA (0.07 μg/kg and 0.2 μg/kg) twice weekly for four weeks via intratracheal instillation. Metabolomic profiling of serum was performed using rapid resolution liquid chromatography coupled with quadrupole time-of-flight tandem mass spectrometry (RRLC/Q-TOF-MS) to elucidate metabolic disruptions caused by DahA exposure.  Results  DahA exposure induced significant oxidative stress and inflammatory responses in rats, accompanied by notable alterations in the serum metabolome. A total of 11 metabolites were found to be decreased, and 2 metabolites were increased, with disruptions observed in folate biosynthesis, glycerophospholipid metabolism, and nitrogen metabolism pathways. Additionally, metabolic dysregulation may interfere with the tricarboxylic acid cycle and compromise nucleotide homeostasis.  Conclusion  These findings enhance our understanding of the toxicological effects of DahA exposure and its role in lung damage. The results suggest that metabolic disturbances caused by DahA may contribute to the exacerbation of respiratory diseases associated with particulate matter-bound PAH pollution during the heating season in cold regions.